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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 202-895-5 | CAS number: 100-85-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 18 April 2018 to 07 May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The substance can be produced through different process routes, yielding solutions in water or organic solvent (e.g. methanol or ethylene glycol).
It was initially unclear how to register the substance (mono-constituent or multi-constituent substance) and which manufactured substance to test to fulfil the REACH data requirements. After consultation with the ECHA helpdesk, the test program was started with the manufactured substance of the Lead registrant (solvent: methanol) in which the highest amount of solvent could be removed without causing degradation of the substance. This resulted in the selection of a solution of 56-57% BTMAOH in methanol as test substance.
During the course of the test program, and in order to aid meaningful risk assessment, after consultation with ECHA and upon ECHA's recommendation, it was considered to be more appropriate to test the water-based manufactured substance. As a consequence, some testing was performed with a BTMAOH solution in methanol, and some testing was performed with a BTMAOH solution in water.
The current entry reflects a test performed with a water-based test solution. - Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- -3
- Temp.:
- 20 °C
- pH:
- 7
- Key result
- Type:
- Pow
- Partition coefficient:
- 0.001
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- - Concentration analysed in the stock solution was 1.03 g/L.
- Nominal quantity of the substance in each test sample: 2.06 mg.
- Recovery (range) for the test samples: 100-104%.
- The log Pow values were within the criterion range of ± 0.3 log units (see table below) - Conclusions:
- The log Pow of BTMAOH at pH 7 and 20°C was determined to be -3.0.
- Executive summary:
The shake-flask method according to EC A.8, OECD 107 and OPPTS 830.7550 was performed (GLP-study). The study was performed with 20% BTMAOH in water. Quantitative analysis was performed on BTMAOH by HPLC-UV. The Pow of BTMAOH at pH 7 and 20°C was determined to be 1.1E-3 with a standard deviation of 2.5E-4. log Pow = -3.0.
Reference
Table: Shake-flask results
Ratio |
Analyzed concentration |
Pow |
log Pow |
pH |
|
n-octanol |
buffer pH 7 |
individual |
|
|
|
1:1 |
0.000400 |
0.344 |
1.2E-3 |
-2.9 |
7.1 |
|
0.000481 |
0.350 |
1.4E-3 |
-2.9 |
7.1 |
1:2 |
0.000388 |
0.266 |
1.5E-3 |
-2.8 |
7.1 |
|
0.000250 |
0.266 |
9.4E-4 |
-3.0 |
7.1 |
2:1 |
0.000457 |
0.528 |
8.7E-4 |
-3.1 |
7.1 |
|
0.000478 |
0.525 |
9.1E-4 |
-3.0 |
7.1 |
Mean |
1.1E-3 |
-3.0 |
|
||
Standard deviation |
2.5E-4 |
|
|
Description of key information
The log Pow of the registered substance BTMAOH at pH 7 and 20°C was determined to be -3.0.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -3
- at the temperature of:
- 20 °C
Additional information
Determined using the shake-flask method, performed with 20% BTMAOH in water. Quantitative analysis was performed on BTMAOH by HPLC-UV.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.