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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Remarks:
Intraperitoneal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2000

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No guideline is specified in the report.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Reference substance name:
Benzoic acid, 5-[(1E)-[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]azo]-2- hydroxy-, disodium salt, dihydrate
Cas Number:
150399-21-6
Molecular formula:
C17H13N3O6Na2 . 2H2O
IUPAC Name:
Benzoic acid, 5-[(1E)-[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]azo]-2- hydroxy-, disodium salt, dihydrate
Test material form:
solid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 0.9% NaCl
Details on exposure:
MAXIMUM DOSE VOLUME APPLIED: 0.2 mL/animal
Doses:
0.5 and 1 g/kg bw
No. of animals per sex per dose:
6 animals per sex per dose
Control animals:
not specified
Details on study design:
All animals were observed for clinical signs and mortality for 7 days. At the end of the observation period, all animals were sacrificed and subjected to complete necropsy.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 1 000 mg/kg bw
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
No mortality was observed during the test.
Clinical signs:
No clinical signs were observed during the test.

Applicant's summary and conclusion

Conclusions:
The acute intraperitoneal non-lethal dose in rats was greater than 1000 mg/kg.