Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 May - 25 May 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Test material: Balsalazide acid
- Batch number: 0400
- Expiry date: April 2019
- Purity: >98%
- Storage: Room temperature
- Stability: 12 months
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
1
Temp.:
25 °C
pH:
7.5
Details on results:
The calibration reference standards consist of 6 reference standards of known log Pow (4-acetylpyridine, aniline, benzyl alcohol, benzonitrile, acetophenone and cinnamyl alcohol). The standards chosen had a log Pow between 0.5 and 1.9.

Table 1: Calibration line of the reference standards

Linear correlation:

Slope

1.5114

Intercept

0.5072

Correlation

0.9929

R2

0.9853

 

Table 2: Results of log Pow of the test item at pH 7.5

Average log Pow

1.00

Agreement (S1-S2)

0.0002

Conclusions:
The partition coefficient (n-octanol/ water, log Pow) of Balsalazide acid was found to be 1.00.

Description of key information

The partition coefficient (n-octanol/ water, log Pow) of the test item, Balsalazide acid was determined according to OECD Guideline 117 and was found to be 1.00.

Key value for chemical safety assessment

Log Kow (Log Pow):
1
at the temperature of:
25 °C

Additional information