Registration Dossier
Registration Dossier
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EC number: 230-908-4 | CAS number: 7365-82-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Referenceopen allclose all
- Reference Type:
- other: computer model
- Title:
- ECOSAR v1.11
- Author:
- US Environmental Protection Agency's Office of Chemical Safety and Pollution Prevention
- Year:
- 2 017
- Bibliographic source:
- https://www.epa.gov/tsca-screening-tools/ecological-structure-activity-relationships-ecosar-predictive-model
- Reference Type:
- other: Estimation software
- Title:
- Estimation Programs Interface Suite for Microsoft Windows, v4.11
- Author:
- US EPA
- Year:
- 2 012
- Bibliographic source:
- United States Environmental Protection Agency, Washington DC, USA; November 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals
- Version / remarks:
- May 2008
- Principles of method if other than guideline:
- QSAR prediction using ECOSAR v1.11.
- GLP compliance:
- no
Test material
- Reference substance name:
- N-(carbamoylmethyl)taurine
- EC Number:
- 230-908-4
- EC Name:
- N-(carbamoylmethyl)taurine
- Cas Number:
- 7365-82-4
- Molecular formula:
- C4H10N2O4S
- IUPAC Name:
- N-(carbamoylmethyl)taurine
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- SMILES : O=C(N)CNCCS(=O)(=O)O
CHEM : N-(carbamoylmethyl)taurine
CAS Num: 7365-82-4
MOL FOR: C4 H10 N2 O4 S1
MOL WT : 182.20
Log Kow: -4.490
Wat Sol: 1E+006
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- other: Green Algae (genus species not reported)
Study design
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 96 h
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 1 320 000 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR
- Remarks:
- Aliphatic Amines-Acid class
- Basis for effect:
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 185 000 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR
- Remarks:
- Amides-acid class
- Basis for effect:
- not specified
- Details on results:
- see QPRF/QMRF
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Predictions toxicity to aquatic plants determined by ECOSAR for N-(carbamoylmethyl) taurine:
Green algae 96-hr EC50: 1.32e+006 mg/L (Aliphatic Amines-acid class) although this chemical may not be soluble enough to measure this predicted effect. If the effect level exceeds the water solubility by 10X, typically no effects at saturation (NES) are reported.
Green Algae 96-hr EC50: 92560.039 mg/L (Amines-acid class). - Executive summary:
Predictions toxicity to aquatic plants determined by ECOSAR for N-(carbamoylmethyl) taurine:
Green algae 96-hr EC50: 1.32e+006 mg/L (Aliphatic Amines-acid class) although this chemical may not be soluble enough to measure this predicted effect. If the effect level exceeds the water solubility by 10X, typically no effects at saturation (NES) are reported.
Green Algae 96-hr EC50: 92560.039 mg/L (Amines-acid class).
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