Registration Dossier
Registration Dossier
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EC number: 230-908-4 | CAS number: 7365-82-4
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to QPRF/QMRF documentation for detailed information on model suitability.
Data source
Reference
- Reference Type:
- other: Modeling software
- Title:
- Chemistry Central Journal
- Author:
- Ferrari T., Gini G.
- Year:
- 2 010
- Bibliographic source:
- 2010, 4(Suppl 1):S2 (29 July 2010)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals
- Version / remarks:
- May 2008
- GLP compliance:
- no
- Type of assay:
- other: QSAR calculation
Test material
- Reference substance name:
- N-(carbamoylmethyl)taurine
- EC Number:
- 230-908-4
- EC Name:
- N-(carbamoylmethyl)taurine
- Cas Number:
- 7365-82-4
- Molecular formula:
- C4H10N2O4S
- IUPAC Name:
- N-(carbamoylmethyl)taurine
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- SMILES: O=C(N)CNCCS(=O)(=O)O
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: modeling based on bacteria
- Metabolic activation:
- not applicable
Results and discussion
Test results
- Key result
- Species / strain:
- bacteria, other: modeling based on bacteria
- Metabolic activation:
- not applicable
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not examined
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- not examined
- Remarks on result:
- other: QSAR Modeling predicition
- Remarks:
- Negative for mutagenicity.
Any other information on results incl. tables
See QPRF/QMRF
Applicant's summary and conclusion
- Conclusions:
- The CAESAR model within the VEGA QSAR software predicted that N-(carbamoylmethyl) taurine is not mutagenic.
- Executive summary:
The CAESAR model within the VEGA QSAR software predicted that N-(carbamoylmethyl) taurine is not mutagenic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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