Registration Dossier
Registration Dossier
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EC number: 700-296-8 | CAS number: 61337-89-1
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 July 2018 - 12 October 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- {2-[(2R)-4-methyl-2-phenylpiperazin-1-yl]pyridin-3-yl}methanol; {2-[(2S)-4-methyl-2-phenylpiperazin-1-yl]pyridin-3-yl}methanol
- EC Number:
- 700-296-8
- Cas Number:
- 61337-89-1
- Molecular formula:
- C17-H21-N3-O
- IUPAC Name:
- {2-[(2R)-4-methyl-2-phenylpiperazin-1-yl]pyridin-3-yl}methanol; {2-[(2S)-4-methyl-2-phenylpiperazin-1-yl]pyridin-3-yl}methanol
- Test material form:
- solid: particulate/powder
- Details on test material:
- Physical appearance: white powder
Storage conditions: at room temperature
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 2.63 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 14 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- 9.3
- Remarks on result:
- other: mean of concentrations measured at all 3 sampling occasions
- Details on results:
- - No test item was detected in the pretreated sample from the blank water mixture.
- Concentration analysed after 24, 48 and 72 hours of stirring: 2.64 g/L, 2.62 g/L and 2.63 g/L, resp.
- Maximum difference meets the criterion of ≤ 15% (i.e. 0.66%)
- The mean of the three concentrations measured at 24, 48 and 72 hours was reported as the water solubility of the substance.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the substance at 20°C was determined to be 2.63 g/L (flask method).
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