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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22 January 2018 - 02 August 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
{2-[(2R)-4-methyl-2-phenylpiperazin-1-yl]pyridin-3-yl}methanol; {2-[(2S)-4-methyl-2-phenylpiperazin-1-yl]pyridin-3-yl}methanol
EC Number:
700-296-8
Cas Number:
61337-89-1
Molecular formula:
C17-H21-N3-O
IUPAC Name:
{2-[(2R)-4-methyl-2-phenylpiperazin-1-yl]pyridin-3-yl}methanol; {2-[(2S)-4-methyl-2-phenylpiperazin-1-yl]pyridin-3-yl}methanol
Test material form:
solid: particulate/powder
Details on test material:
Physical appearance: white powder
Storage conditions: at room temperature
Specific details on test material used for the study:
Decomposition temp.: > 275°C

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
0 Pa

Any other information on results incl. tables

Results of the isothermal TGA analysis (test item)

Temperature
[°C]

Weight loss
[µg/min]

ν(T)
[g/cm2/h]

log ν(T)

log P(T)

P(T)
[Pa]

100

0.443297

5.29 x10 -5

-4.28

-0.34

0.46

 

0.425459

5.08 x10 -5

-4.29

-0.36

0.44

110

1.06989

1.28 x10 -4

-3.89

0.15

1.4

 

1.05172

1.26 x10 -4

-3.90

0.14

1.4

120

2.67352

3.19 x10 -4

-3.50

0.66

4.6

 

2.71262

3.24 x10 -4

-3.49

0.67

4.7

Vapour Pressure of the Test Item

Temperature
[°C]

logPT

PT
[Pa]

PT
[mm Hg]

20

-5.80

1.6 x 10 -6

1.2 x 10 -8

25

-5.37

4.3 x 10 -6

3.2 x 10 -8

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the substance at 20°C was determined to be 1.6E-6 Pa.
The vapour pressure of the substance at 25°C was determined to be 4.3E-6 Pa.
Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950.

The constants specific for the experimental arrangement were determined using a set of 5 reference compounds. A vapour pressure curve for the test item was constructed from duplicate measurements at 100°C, 110°C, and 120°C. The vapour pressure of the substance at 20°C and 25°C was calculated by extrapolation to be 1.6E-6 Pa and 4.3E-6 Pa, resp.