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Ecotoxicological information

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Reliable GLP compliant aquatic acute ecotoxicity test results are available for fish, invertebrates and algae. An OECD 203 study reported a 96-h LC50 forBrachydanio rerioof >10 mg/L (corresponding to >5.35 mg F/L) (Solvay Pharmaceuticals, 2010a) and an OECD 202 study showed that the 48-h EC50 inDaphnia magnais 22.8 mg/L (corresponding to 12.2 mg F/L) (Solvay Pharmaceuticals, 1999). These values will be used for the assessment.

For algae two growth inhibition tests were performed with the algal speciesPseudokirchneriella subcapitataaccording to OECD Guideline 201(ECT Oekotoxikologie, 2012a and b). The tests have been conducted with two different batches of aluminium potassium fluoride: Nocolok Flux and Hot melt PAF. The 72-h EC50 values for growth rate were 33.5 and 12.7 mg/l (corresponding to 17.4 and 7.0 mg F/L). The 72 hr NOErC values were reported to be 11 and 4.3 mg/l (corresponding to 5.7 and 2.4 mg F/L), respectively. The lowest values (ErC50 of 12.7 mg/l and NOErC of 4.3 mg/l) will be used in the assessment.

Long-term ecotoxicity tests with fish and invertebrates are not available.

One GLP-compliant OECD 209 guideline study is available for the toxicity to microorganisms. The 3-h EC50 and 3-h NOEC were both >75 mg/L (corresponding to >40 mg F/L) in activated sludge (Solvay Pharmaceuticals, 2010c).