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EC number: 429-380-1
CAS number: 133336-92-2
An assessment of acute oral toxicity with KY-AF in the rat was performed
according to EC test guideline and in accordance with GLP principles.
KY-AF was administired by oral gavage to 5 male and 5 female Wistar rats
at 2000 mg/kg bw. No mortality occured. Lethargy and uncoordinated
movements were observed in all animals on day 1 and one male also showed
hunched posture. The body weight gain shown by the animals over the
study period was considered to be similar to that expected for normal
untreated animals of the same age and strain. No abnormalities were
found at macroscopic post mortem examination of the animals. The oral
LD50 value of KY-AF in Wistar rats was established to exceed 2000 mg/kg
Based on these results, KY-AF does not have to be classified and has no
obligatory labelling requirement for acute oral toxicity according to
the Globally Harmonized System of Classification and Labelling of
Chemicals (GHS) of the United Nations (2015) (including all amendments)
and Regulation (EC) No 1272/2008 on classification, labelling and
packaging of items and mixtures (including all amendments).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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