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EC number: 250-264-8 | CAS number: 30618-84-9
The subacute oral NOAEL for GMT is 50 mg/kg bw/day.
Table 1: Summary of Local Skin Reactions
Local skin reactions after:
No skin reactions
treated with test substance
Table 2: Continued summary of Local Skin Reactions
Noticeable hair loss 6/10, severe hair loss 3/10, complete hair loss 1/10
Noticeable hair loss 4/10, severe hair loss 5/10, complete hair loss 1/10
Noticeable hair loss 2/10, severe hair loss 6/10, complete hair loss 2/10
The oral administration of GMT 80% to rats by gavage for 28 days OECD 422 at dose levels of 15, 50 and 150 mg/kg bw/day, resulted in no treatment related effects for the males treated with 150 mg/kg bw/day, but did result in the death of five females treated with 150 mg/kg bw/day. The NOEL for systemic toxicity was considered to be 150 mg/kg/day for males and 50 mg/kg bw/day for females. The relative magnitude of the NOEL was confirmed by an oral 90d study with NaTG (OECD 408, Rousseau, 2010). The anion of the NaTG salt is a potential main metabolite of GMT in vivo and very probably responsible for the toxicity of GMT in vivo.
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