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EC number: 205-252-7
CAS number: 136-60-7
Skin irritation/corrosion: The test item was demonstrated to be
non-irritant in an in vivo study in rabbits performed according to OECD
guideline 404 and EU Method B.4 and conform GLP requirements (Vasquez,
Eye irritation: The test item was demonstrated to be non-irritant
to eyes in an in vivo study in rabbits performed according to OECD
guideline 405 and EU Method B.5 and conform GLP requirements (Vasquez,
One reliable (Klimisch 2) in vivo study is available (Vasquez,
2012). This study in rabbits was performed according to OECD guideline
404 (Acute Dermal Irritation/Corrosion) and EU Method B.4 (Acute
Toxicity: Dermal Irritation/Corrosion) and conform GLP requirements.
After 3 minutes of exposure, no erythema and no edema were observed.
After 60 minutes of exposure, well-defined erythema and no edema was
observed. After 4 hours of exposure well-defined erythema with slight
edema was observed. No other skin responses were noted after the 3
minutes, 60 minutes and 4 hour exposure. Based on these results, the
test item is considered not classified according to the CLP Regulation.
One reliable (Klimisch 2) is available (Vasquez, 2012) was
performed according to OECD guideline 405 (Acute Eye
Irritation/Corrosion) and EU Method B.5 (Acute Toxicity: Eye
Irritation/Corrosion) and conform GLP requirements. No corneal or iris
irritation was observed in the treated eyes of the rabbits at any time
point. Conjunctival redness and chemosis (scores of '1') were observed
at 1 and 24 hours post dose with only one score of '1' observed at 48
hours for redness. Scores of '2' for discharge were observed at 1 hour.
All three animals were observed to be normal at 72 hours. The test
substance was found to be non-irritating to the eye according to the CLP
The test substance was demonstrated to be non-irritating to skin
and eyes and is therefore not to be classified according to the CLP
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