Registration Dossier
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EC number: 948-020-7 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9 November 2017 to 6 September 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Purity: >99% (UVCB)
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 12 - < 14
- Temp.:
- 20 °C
- pH:
- 7
- Conclusions:
- The log partition coefficient (log Pow) of the test material was determined to be greater than 6.5 (the highest log Pow of the reference standards tested (p,p-DDT); the log Pow of the test material has been reported as > 12 - < 14 (the test material is a UVCB).
- Executive summary:
The log Pow of the test material was estimated using high performance liquid chromatography (HPLC) as described by guideline OECD 117, under GLP conditions.
The log partition coefficients (log Pow) were determined based on the mean retention times of the four major components comprising the test substance, and the values were extrapolatedb beyond the upper limit of the calibration curve provided by p,p-DDT with a log Pow of 6.5. The resulting log partition coefficient of the test substance is therefore considered a limit value.
The log partition coefficient (log Pow) of the test material was determined to be greater than 6.5 (the highest log Pow of the reference standards tested (p,p-DDT); the log Pow of the test material has been reported as > 12 - < 14 (the test material is a UVCB).
Reference
Mean Results of HPLC Analyses
Peak |
Mean Retention Time (minutes) |
Mean Calculated log Pow |
Mean Reported log Pow |
1 |
47.893 |
11.783 |
12 |
2 |
73.983 |
12.853 |
13 |
3 |
105.468 |
13.716 |
14 |
4 |
112.908 |
13.88 |
14 |
Description of key information
The log Pow of the test material was estimated using high performance liquid chromatography (HPLC) as described by guideline OECD 117, under GLP conditions. The log partition coefficient (log Pow) of the test material was determined to be greater than 6.5 (the highest log Pow of the reference standards tested (p,p-DDT); the log Pow of the test material has been reported as > 12 - < 14 (the test material is a UVCB).
Key value for chemical safety assessment
Additional information
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