Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 942-582-7 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.86 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Dose descriptor starting point:
- NOAEL
- Value:
- 79 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 139.3 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Dose descriptor calculation:
Oral absorption rate: both oral and inhalation absorptions set at 50 % (oral absorption not expected to be lower than the inhalation absorption)
NOAEL oral * (1/SRV) * sRV*ABS = 79*(1/0.38)*(0.67)*(1) = 139.3 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- default value
- AF for differences in duration of exposure:
- 6
- Justification:
- for extrapolation subacute to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- default value systemic effect for conversion of oral dose to inhalation concentration, using the section R.8.4.2 of the REACh guidance document
- AF for other interspecies differences:
- 2.5
- Justification:
- default value systemic effect
- AF for intraspecies differences:
- 5
- Justification:
- default value for worker
- AF for the quality of the whole database:
- 1
- Justification:
- reliability 1 or 2 data
- AF for remaining uncertainties:
- 1
- Justification:
- not concerned
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.26 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEL
- Value:
- 79 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 79 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Dose descriptor calculation:
Default value of oral-to- dermal extrapolation = 1 (oral and dermal absorption both set at 50%)
NOAEL oral *ABS = 79*1 = 79 mg/kg bw/d
- AF for dose response relationship:
- 1
- Justification:
- default value
- AF for differences in duration of exposure:
- 6
- Justification:
- for extrapolation subacute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- factor for allometric scaling (4 for rat)
- AF for other interspecies differences:
- 2.5
- Justification:
- default value systemic effect
- AF for intraspecies differences:
- 5
- Justification:
- default value for worker
- AF for the quality of the whole database:
- 1
- Justification:
- reliability 1 or 2 data
- AF for remaining uncertainties:
- 1
- Justification:
- not concerned
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.46 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Dose descriptor starting point:
- NOAEL
- Value:
- 79 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 68.7 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Dose descriptor calculation:
Oral absorption rate: both oral and inhalation absorptions set at 50 % (oral absorption not expected to be lower than the inhalation absorption)
NOAEL oral * (1/SRV) * ABS = 79*(1/1.15)* (1) = 68.7 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- default value
- AF for differences in duration of exposure:
- 6
- Justification:
- for extrapolation subacute to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- default value for conversion of oral dose to inhalation concentration, using the section R.8.4.2 of the REACh guidance document
- AF for other interspecies differences:
- 2.5
- Justification:
- default value systemic effect
- AF for intraspecies differences:
- 10
- Justification:
- default value general population
- AF for the quality of the whole database:
- 1
- Justification:
- reliability 1 or 2 data
- AF for remaining uncertainties:
- 1
- Justification:
- not concerned
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.13 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 79 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 79 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Dose descriptor calculation:
Default value of oral-to- dermal extrapolation = 1 (oral and dermal absorption both set at 50%)
NOAEL oral *ABS = 79*1 = 79 mg/kg bw/d
- AF for dose response relationship:
- 1
- Justification:
- default value
- AF for differences in duration of exposure:
- 6
- Justification:
- for extrapolation subacute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- factor for allometric scaling (4 for rat)
- AF for other interspecies differences:
- 2.5
- Justification:
- default value systemic effect
- AF for intraspecies differences:
- 10
- Justification:
- default value for general population
- AF for the quality of the whole database:
- 1
- Justification:
- reliability 1 and 2 data
- AF for remaining uncertainties:
- 1
- Justification:
- not concerned
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.13 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 79 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 79 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Dose descriptor calculation:
No route to route extrapolation applicable (oral route data)
- AF for dose response relationship:
- 1
- Justification:
- default value
- AF for differences in duration of exposure:
- 6
- Justification:
- for extrapolation subacute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- factor for allometric scaling (4 for rat)
- AF for other interspecies differences:
- 2.5
- Justification:
- default value systemic effect
- AF for intraspecies differences:
- 10
- Justification:
- default value for general population
- AF for the quality of the whole database:
- 1
- Justification:
- reliability 1 and 2 data
- AF for remaining uncertainties:
- 1
- Justification:
- not concerned
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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