Registration Dossier

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: observation in humans
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
other: safety data sheet
Title:
Safety data sheet - N-ethyl-2-methylaniline
Author:
Supplier of the substance
Year:
2014

Materials and methods

Endpoint addressed:
acute toxicity: inhalation
Test guideline
Qualifier:
no guideline required
GLP compliance:
no
Remarks:
not relevant

Test material

Specific details on test material used for the study:
not specified

Method

Ethical approval:
not specified
Exposure assessment:
not specified
Details on exposure:
inhalation

Results and discussion

Results:
Clinical signs of intoxication in humans include methaemoglobinaemia and haematuria. An exposure of 40 ppm of toluidine (all isomers) in air for 60 minutes produces severe intoxication. Prolonged exposure to as little as 10 ppm was reported to cause symptoms of illness.

Applicant's summary and conclusion

Conclusions:
Clinical signs of intoxication in humans include methaemoglobinaemia and haematuria. An exposure of 40 ppm of toluidine (all isomers) in air tor 60 minutes produces severe intoxication. Prolonged exposure to as little as 10 ppm was reported to cause symptoms of illness.