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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 January 2018 - 26 March 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to
Guideline:
other: European Commission Technical Guidance Document EUR 20268 Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances (2002).
GLP compliance:
yes (incl. certificate)
Type of method:
cascade impaction
Type of particle tested:
primary particle
Type of distribution:
mass based distribution
Specific details on test material used for the study:
Identification: RM10000077
Chemical name: Zinc oxide phosphite (CAS 64539-51-1)
Appearance/Physical state: white powder
Lot No: 1013Q17761
Purity: 62% (zinc content)
Expiry date: 25 June 2018
Storage conditions: room temperature, in the dark
Mass median aerodynamic diameter:
<= 100 µm
Key result
Percentile:
other: 98.8
Mean:
<= 100 µm
Remarks on result:
other: Mean and St.dev not specified
No.:
#1
Size:
<= 100 µm
Distribution:
ca. 98.8 %

 Measurement  Method  Result
 Percentage of test item with an inhalable particle size <100 μm Sieve   98.8%
 Percentage of test item with a thoracic particle size <10.0 μm Cascade Impactor   < 0.1%
 Percentage of test item with a respirable particle size <5.5 μm Cascade Impactor   < 0.1%
Conclusions:
The percentage of test item with an inhalable particle size <100 μm was 98.8% of cumulative mass.
Executive summary:

Particle size data was acquired, using a procedure designed to be compatible with the European Commission Technical Guidance Document EUR 20268 Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances (2002). The results are as follows:

 Measurement  Method  Result
 Percentage of test item with an inhalable particle size <100 μm Sieve   98.8%
 Percentage of test item with a thoracic particle size <10.0 μm Cascade Impactor   < 0.1%
 Percentage of test item with a respirable particle size <5.5 μm Cascade Impactor   < 0.1%

Description of key information

The percentage of test item with an inhalable particle size <100 μm was 98.8% of cumulative mass.

Additional information