Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Version / remarks:
The used method refers to the Directive 92/69 published in the
Official Journal of European Community No. L 383 A/5 of
29/12/1992 (method A.8. - section 1.6.2.).
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
gas chromatography
Key result
Type:
log Pow
Partition coefficient:
1.8
Temp.:
25 °C
Remarks on result:
other: Determined using the water solubility result from laboratory conducting ecotoxicological testing (8 mg/L)
Type:
log Pow
Partition coefficient:
> 1.7
Temp.:
25 °C
Remarks on result:
other: The water solubility value was determined as <10 mg/L. Therefore it was not possible to determine the precise log Kow (estimated >1.7)
Conclusions:
The partition coefficient (log Kow) was determined to be 1.8 based on a water solubility value of 8 mg/L
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
July 27 1995
GLP compliance:
not specified
Type of method:
flask method
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
ca. 3.47
Temp.:
24 °C
Remarks on result:
other: pH not stated
Conclusions:
The log Pow was determined to be ca. 3.47 under the conditions of the test.

Description of key information

Two studies were available to assess the partition coefficient of the substance. Each study used the flask method and the Log Kow was determined to be between 1.7 and 3.47. The conservative value of 3.47 is used in the chemical safety assessment.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.47
at the temperature of:
24 °C

Additional information