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EC number: 808-234-2 | CAS number: 1211443-61-6
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 Feb - 07 Mar 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- August 24, 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- March 23, 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Version / remarks:
- August 1996
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- effusion method: isothermal thermogravimetry
Test material
- Reference substance name:
- 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
- Cas Number:
- 1211443-61-6
- Molecular formula:
- C14 H17 Cl N4 O
- IUPAC Name:
- 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Constituent 1
Results and discussion
Vapour pressureopen allclose all
- Temp.:
- 20 °C
- Vapour pressure:
- <= 0 Pa
- Temp.:
- 25 °C
- Vapour pressure:
- <= 0 Pa
Any other information on results incl. tables
The equation of the curve was: log PT = -5746 * 1/T + 14.89 (r = 0.995, n = 8).
The results of the isothermal TGA analysis for the test substance and the vapour pressure at 20 °C and 25 °C are given in the following tables.
Results of the isothermal TGA analysis
Temperature [°C] |
Weight loss [μg/min] |
νT [g/cm²/h] |
log νT |
log PT |
PT [Pa] |
130 |
3.224 |
3.85E-4 |
-3.41 |
0.70 |
5.0 |
130 |
2.527 |
3.02E-4 |
-3.52 |
0.58 |
3.8 |
140 |
6.007 |
7.17E-4 |
-3.14 |
1.01 |
10 |
140 |
5.379 |
6.42E-4 |
-3.19 |
0.96 |
9.0 |
150 |
11.31 |
1.35E-3 |
-2.87 |
1.32 |
21 |
150 |
10.50 |
1.25E-3 |
-2.90 |
1.29 |
19 |
160 |
21.06 |
2.51E-3 |
-2.60 |
1.63 |
43 |
160 |
20.71 |
2.47E-3 |
-2.61 |
1.63 |
42 |
Vapour pressure of the test substance
Temperature [°C] |
log PT |
PT [Pa] |
PT [mm Hg] |
20 |
-4.71 |
2.0E-5 |
1.5E-7 |
25 |
-4.38 |
4.2E-5 |
3.1E-7 |
Conclusion
The vapour pressure values of the test substance at 20 °C (293K) and 25 °C (298K) were ≤ 2.0E-5 Pa and ≤ 4.2E-5 Pa, respectively. The weight losses were obtained with a temperature program of above the melting temperature of the test substance and are therefore reported as ≤ values.
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure of the substance was determined to be ≤ 2.0E-5 Pa and ≤ 4.2E-5 Pa at 20 °C and 25 °C, respectively.
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