Triphenyl phosphite

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Report date:

1970

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

according to internal standard method

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triphenyl phosphite

EC Number:

202-908-4

EC Name:

Triphenyl phosphite

Cas Number:

101-02-0

Molecular formula:

C18H15O3P

IUPAC Name:

triphenyl phosphite

Test animals

Species:

mouse

Strain:

other: Kislegg

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: between 24 and 43 g

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

other: aequous emulsion with Traganth

Details on exposure:

- Concentration in vehicle: 2% and 4%

Doses:

200, 250, 320, 400 mg/kg

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 253 mg/kg bw

Mortality:

All animals treated with 400 mg/kg died. At 320 mg/kg 4/5 males and 3/5 females died, at 250 mg/kg, 3/5 males and 3% females died. At 200 mg/kg one male and one female died.

Clinical signs:

Immediately after administration accelerated breathing, caved in sides, unsteady gait and flattened ears. After 3.5 hours animals appeared sedated, irregular breathing, closed eye lids, ruffled fur. During the observation period animals showed ruffeld fur, rapid breathing and curved pody position and bad general health. Recovery from these symptoms after 10 to 11 days.

Gross pathology:

Occationally substance incorporation into the spleen and liver, adhesions in the liver

Applicant's summary and conclusion

Conclusions:

Based on the results of this acute IP toxicity study in Kislegg mice, the LD50 was set to 253 mg/kg bw for males and females.