Registration Dossier
Registration Dossier
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EC number: 219-075-8 | CAS number: 2349-07-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- Maximization test on human volunteers
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs
- Year:
- 1 982
- Bibliographic source:
- Food and Chemical Toxicology. Vol. 20, Pg. 719
Materials and methods
- Type of study:
- other: Maximization test on human volunteers
Test material
- Reference substance name:
- Hexyl isobutyrate
- EC Number:
- 219-075-8
- EC Name:
- Hexyl isobutyrate
- Cas Number:
- 2349-07-7
- Molecular formula:
- C10H20O2
- IUPAC Name:
- hexyl 2-methylpropanoate
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- Material: RIFM no. 77-221
In vivo test system
Test animals
- Species:
- other: human
Results and discussion
Any other information on results incl. tables
A maximization test was carried out on 25 volunteers. The material (RIFM no.77 -221) was tested at a concentration of 4% in petrolatum and produced no sensitization reactions. No further information is given.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Hexyl isobutyrate (4% in petrolatum) produced no sensitization reactions in 25 human volunteers.
- Executive summary:
Secondary literature data:
A maximization test (1, 2) was carried out on 25 volunteers. The material (RIFM no.77 -221) was tested at a concentration of 4% in petrolatum and produced no sensitization reactions (3).
(1) Kligman, A. M. (1966). The identification of contact allergens by human assay. III. The maximizarion test. A procedure for screening and rating contact sensitizers. J. invest. Derm. 47, 393.
(2) Kligman, A. M. & Epstein, W. (1975). Updating the maximization test for identifying contact allergens. Contact Dermatitis 1, 231.
(3) Kligman, A. M. (1977). Report to RIFM, 15 September.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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