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EC number: 947-748-2 | CAS number: -
Table: Survival, growth and reproduction averages for all endpoints of Daphnia magna at the end of the 21 d exposure period to the test item compared to the control treatment.
Nominal treatment loading
Growth(length on day 21)
Age at first brood
Cumulative offspring per female
Mean ± SD (mm)
Mean ± SD (days)
Mean ± SD (n)
3.98 ± 0.26
10.2 ± 0.95
64.7 ± 12.44
3.74 ± 0.3
10.8 ± 1.06
66.1 ± 9.08
≥ 1 mg/L
n.d.: not able to determine as there were effects at the response level
Since no studies investigating the long-term toxicity of Fatty acids lanolin, di, tri- and tetraesters with pentaerythritol and rape fatty acid to aquatic invertebrates are available, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5, a read-across to the structurally related source substance Fatty acids, C16-18 and C18-unsatd., esters with pentaerythritol (CAS 85711-45-1) was conducted.
The source substance is representative to evaluate the short-term toxicity of the target substance to aquatic invertebrates. This read-across is justified in detail within the analogue justification in IUCLID Section 13.
The target substance Fatty acids lanolin, di, tri- and tetraesters with pentaerythritol and rape fatty acid is characterized as a UVCB substance with pentaerythritol as alcohol component. Esterification of pentaerythritol gives mainly tri- and tetraesters of long chain fatty acids C16-C20.
The source substance Fatty acids, C16-18 and C18-unsatd., esters with pentaerythritol (CAS 85711-45-1) is characterized as a UVCB substance with pentaerythritol as alcohol component. Esterification of pentaerythritol gives a mixed degree of esters of mainly C16-C18 fatty acids.
The study with the source substance Fatty acids, C16-18 and C18-unsatd., esters with pentaerythritol (CAS 85711-45-1) was performed in a semi-static test design according to OECD 211 (GLP).Daphnia magnawere exposed to a single nominal loading rate of 1 mg/L (prepared as WAF). No immobility and no sub-lethal effects were observed after an exposure period of 21 days. Hence a NOELR of ≥ 1 mg/L was determined.
Based on the results for the structurally related read-across substance (in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that no long-term toxicity of the target substance Fatty acids lanolin, di, tri- and tetraesters with pentaerythritol and rape fatty acid to aquatic invertebrates is expected up to the limit of the water solubility (< 0.15 mg/L).
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