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EC number: 205-009-5 | CAS number: 131-08-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- To one male and two female rabbits about 0.5 ml of undiluted Luprintan TX 4493 (= Anthraquinone-2-sulfonic acid sodium salt) was applied for 4 hours to the upper third of the back or flanks. At the end of the exposure period the test substance was removed with lutrol and lutrol/water 1:1. Readings according to Draize were done 30-60 min after removal of the test patches and 24, 48 and 72 hours after the beginning of the application.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium 9,10-dihydro-9,10-dioxoanthracene-2-sulphonate
- EC Number:
- 205-009-5
- EC Name:
- Sodium 9,10-dihydro-9,10-dioxoanthracene-2-sulphonate
- Cas Number:
- 131-08-8
- Molecular formula:
- C14H8O5S.Na
- IUPAC Name:
- sodium 9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- Animals species: Rabbit / White Vienna
Animal breeder: Gaukler, D-6050 Offenbach, FRG
Acclimatisation: At least 8 days before the beginning of the study
Type of cage: Stainless steel wire mesh walk floors (40 cm x 51 cm)
No. animals per cage: 1
Room temperature/ The animals were housed in fully air-conditioned rooms (20 - 24°C; relative humidity 30 - 70°C).
relative humidity
Day/night rhythm: 12 hours / 12 hours
Drinking water: About 250 ml tap water per animal per day
Diet: Kliba 341
Clipping of the fur: At least 15 hours before the beginning of the study
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml on a test patch (2.5 cm x 2.5 cm)
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 1 male and 2 females
- Details on study design:
- Exposure period: 4 hours
Number of animals: 1 male and 2 female rabbits
Mean weight: male: 3.00 kg; female: 3.05 kg
Application area: 2.5 cm x 2.5 cm
Form of application: unchanged
Application volume: wetting of the test patch (2.5 cm x 2.5 cm) with the undiluted substance, and thus about 0.5 ml of the test liquid was absorbed
Application site: upper third of the back or flanks
Removal of test substance: at the end of the exposure period with lutrol and lutrol/water (1:1)
Observation period: 72 hours
Readings: 30 - 60 minutes after removal of the test patches and 24, 48 and 72 hours after the beginning of the application
Negative control: untreated skin sites of the same animal
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point
- Irritant / corrosive response data:
- Erythema and edema score = 0 at any time point (24, 48 and 72 hours).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No erythema and no edema was found at any time point (24, 48 and 72 hours).
- Executive summary:
To one male and two female rabbits about 0.5 ml of undiluted Luprintan TX 4493 (= Anthraquinone-2-sulfonic acid sodium salt) was applied for 4 hours to the upper third of the back or flanks. At the end of the exposure period the test substance was removed with lutrol and lutrol/water 1:1. Readings according to Draize were done 30-60 min after removal of the test patches and 24, 48 and 72 hours after the beginning of the application. No erythema and no edema was found at 24, 48 and 72 hours. Therefore Luprintan TX 4493 (= Anthraquinone-2-sulfonic acid sodium salt) is not skin irritating.
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