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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
N.N.
Author:
N.N.
Year:
1972
Bibliographic source:
National Technical Information Service. Vol. OTS0555171,
Reference Type:
publication
Title:
Can Acute Dermal Systemic Toxicity Tests Be Replaced With Oral Tests? A Comparison of Route-Specific Systemic Toxicity and Hazard Classifications Under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
Author:
Nigel et all
Year:
2013
Bibliographic source:
Regulatory Toxicology and Pharmacology, 66(1), 30-37.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no guideline identified in National Technical Information Service. Vol. OTS0555171
GLP compliance:
no
Test type:
other: other unknown
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ditin pyrophosphate
EC Number:
239-635-5
EC Name:
Ditin pyrophosphate
Cas Number:
15578-26-4
Molecular formula:
H4O7P2.2Sn
IUPAC Name:
ditin pyrophosphate
Test material form:
solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
other: not relevant
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 850 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Oral LD50 = 3850, so the dose for dermal toxicity is also higher than 2000 mg/kg bw