Propanamide, N-[2-(4-phenoxyphenoxy)ethyl]-

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1987

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

Details on test item, housing conditions are missing

GLP compliance:

no

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

N-[2-(4-phenoxyphenoxy)ethyl]propanamide

EC Number:

600-606-0

Cas Number:

104825-66-3

Molecular formula:

C17H19NO3

IUPAC Name:

N-[2-(4-phenoxyphenoxy)ethyl]propanamide

Test material form:

solid

Details on test material:

Appearance: brown-beige solid
Molecular weight: 286
Melting point: 110 °C
Not soluble in water, PEG400 and oilve oil

Specific details on test material used for the study:

Appearance: brown-beige solid
Test item name (as cited in the report): para phenoxy phenoxy ethyl propionamid
Molecular weight: 286
Melting point: 110 °C
Not soluble in water, PEG400 and oilve oil

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

Initial weight: 210 ± 10 g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

DMSO

Remarks:

20% (w/v)

Details on oral exposure:

The test item was not soluble in water, PEG400 and oilve oil. It was diluted in DMSO at 20 % (200 mg/mL)

Doses:

0.5, 1, 2, 3, 3.5, and 4 g/kg bw

No. of animals per sex per dose:

10/dose

Control animals:

no

Details on study design:

Animals were fasted at 5 PM the day before administration and they are fed again 3 h after administration.
Administration occured at 10 AM.
Animals were observed daily for 14 days.
Survivals are weighed the 7th day after administration.
Macroscopic examination was performed at sacrifice or in prematurely dead animals.

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

3 750 mg/kg bw

Based on:

test mat.

Mortality:

1/10 at 3 g/kg bw (on Day 1), 3/10 at 3.5 g/kg bw (on Day 2) and 7/10 (on Day 2) at 4 g/kg bw

Clinical signs:

other: No data

Gross pathology:

No findings

Other findings:

None

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

Under the test conditions, a LD50 of 3750 mg/kg bw was found in male Wistar rats with test item in DMSO (20 % (w/v))

Executive summary:

Groups of 10 fasted male Wistar rats were administered para phenoxy phenoxy ethyl propionamid in DMSO (20% (w/v)) at 0.5, 1, 2, 3, 3.5 and 4 g/kg bw by gavage. They were observed for 14 days and weighed on Day 7. 1 rat/10 at 3 g/kg bw (on Day 1), 3 rats/10 at 3.5 g/kg bw (on Day 2) and 7 rats/10 (on Day 2) at 4 g/kg bw died. No macroscopic findings were recorded in dead animals or survivals. Under the test conditions, a LD50 of 3750 mg/kg bw was determined. Therefore the substance is not classified according to CLP regulation and is classified category 5 (H303) according to GHS.