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EC number: 268-369-2 | CAS number: 68082-25-7 This substance is identified by SDA Substance Name: C14-C18 and C16-C18 unsaturated alkyl carboxylic acid triethanol amine salt and SDA Reporting Number: 04-006-14.
The test item TEA Trioleate was investigated for its potential to induce gene mutations according to the plate incorporation test (experiment I and II) using Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537 and TA 102.
In two independent experiments several concentrations of the test item were used. Each assay was conducted with and without metabolic activation. The concentrations, including the controls, were tested in triplicate. The following concentrations of the test item were prepared and used in the experiments:
10.0, 31.6, 100, 316, 1000 and 2500 μg/plate
5.0, 15.8, 50.0, 158, 500, 1580 and 5000 μg/plate
Precipitation of the test item was observed in all tester strains used in experiment I and II (with and without metabolic activation). In experiment I precipitation of the test item was found at concentrations of 1000 μg/plate and higher (with and without metabolic activation). In experiment II precipitation of the test item was found at a concentration of 5000 μg/plate (with and without metabolic activation).
Toxic effects of the test item were noted in some tester strains evaluated in experiment I and II.
In experiment I toxic effects of the test item were observed in tester strain TA 100 at concentrations of 1000 μg/plate and higher (without metabolic activation). In tester strain TA 1535 toxic effects of the test item were noted at a concentration of 2500 μg/plate (without metabolic activation). In tester strain TA 1537 toxic effects of the test item were observed at a concentration of 2500 μg/plate (with metabolic activation).
In experiment II toxic effects of the test item were noted in tester strain TA 1537 at concentrations of 1580 μg/plate and higher (without metabolic activation).
No biologically relevant increases in revertant colony numbers of any of the five tester strains were observed following treatment with TEA Trioleate at any concentration level, neither in the presence nor absence of metabolic activation in experiment I and II.
All criteria of validity were met.
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