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No experimental studies regarding toxicokinetics of TEA Trioleate are available. Nevertheless available data from literature and information derived from the testing strategy adopted for the chemical, permit to evaluate main aspects of the substance toxicokinetics.

Dermal absorption studies of TEA were performed in vitro using human skin samples and in vivo using mice and rats. In vitro, the absorption of TEA through human skin was low under conditions simulating perceived cosmetic use, that is, 1% to 5% at pH 7.0; approximately 5.5% to 9.5% of the dose was recovered in the skin after 24 or 72 hours; however, only ~0.5% was recovered in the receptor fluid. In mice, [C14]triethanolamine in acetone was rapidly absorbed and absorption and absorption increased with increasing dose. The majority of the radioactivity was excreted in the urine, 48% to 56% in 72 hours, primarily as unchanged TEA. The TEA was absorbed more slowly and less extensively in rats than in mice. In rats, 19% to 28% of the dose was absorbed over a 72-hour period, and 13% to 24% of the dose was recovered in the urine, mostly unchanged TEA. In an oral dosing study with rats, TEA was rapidly absorbed in the gastrointestinal tract and excreted mostly in the form of unchanged TEA (CIR, 2013. Safety Assessment of Triethanolamine and Triethanolamine-Containing Ingredients as Used in Cosmetics. International Journal of Toxicology 32 (supplement I) 59S-83S).

Considering the logKOW > 4.5, bioaccumulation may occur.

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