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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Non-pathogen-free subjects used
Justification for type of information:
Saturated perfluorocarbons are well-established as a class of materials with essentially identical toxicological properties.

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1992

Materials and methods

Principles of method if other than guideline:
Exposed to ca. 10% octafluoropropane in air for 10 days continuously.
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Octafluoropropane
EC Number:
200-941-9
EC Name:
Octafluoropropane
Cas Number:
76-19-7
Molecular formula:
C3F8
IUPAC Name:
1,1,1,2,2,3,3,3-Octafluoropropane
Test material form:
other: gas

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of doses or concentrations:
yes
Details on analytical verification of doses or concentrations:
IR and GLC
Duration of treatment / exposure:
10 days
Frequency of treatment:
Continuous (24hr/day)
No. of animals per sex per dose:
10
Control animals:
yes, concurrent vehicle

Examinations

Observations and examinations performed and frequency:
Observed for bavioural and clinical symptoms daily, weighed at day 0, 5 and 10
Sacrifice and pathology:
All sacrificed, macroscopic examination

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Body weight and weight changes:
no effects observed
Food consumption and compound intake (if feeding study):
not examined
Food efficiency:
not examined
Water consumption and compound intake (if drinking water study):
not examined
Ophthalmological findings:
not examined
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not examined
Behaviour (functional findings):
no effects observed
Organ weight findings including organ / body weight ratios:
effects observed, non-treatment-related
Description (incidence and severity):
Ratio of liver and adrenal weight to body weight increased in females.
Gross pathological findings:
no effects observed
Histopathological findings: non-neoplastic:
effects observed, non-treatment-related
Description (incidence and severity):
Interstitial pneumonitis found to be present in all control and test animals
Histopathological findings: neoplastic:
not specified

Effect levels

Key result
Dose descriptor:
conc. level:
Effect level:
ca. 113 000 ppm
Based on:
test mat.
Sex:
male/female
Basis for effect level:
behaviour (functional findings)
body weight and weight gain
clinical signs
mortality

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Non-pathogen-free subjects were used. Two males in the test group and one in the control were sacrificed on day 6 due to illness. All control and test subhjects were later found to have interstitial pneumonitis.

Applicant's summary and conclusion

Conclusions:
Material is not chronically toxic, even at high concentration.
Executive summary:

Material is not chronically toxic, even at high concentration.