Registration Dossier
Registration Dossier
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EC number: 206-192-4 | CAS number: 306-94-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Remarks:
- other: Single application to rabbits eye
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Saturated perfluorocarbons have very similar toxicological properties and so a "read across" approach is justified.
Note that this is old data from testing done in 1996.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Nonafluoro(trifluoromethyl)cyclopentane
- EC Number:
- 217-298-5
- EC Name:
- Nonafluoro(trifluoromethyl)cyclopentane
- Cas Number:
- 1805-22-7
- Molecular formula:
- C6F12
- IUPAC Name:
- 1,1,2,2,3,3,4,4,5-Nonafluoro-5-(trifluoromethyl)cyclopentane
- Test material form:
- other: liquid
- Details on test material:
- Room temperature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Temperature 17-21 degrees C
Humidity 60-66%
12 hours of light and 12 hours of darkness
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- 0.1ml applied into right eye
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 1, 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 16
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 10
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 4
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Modified Kay & Calandra intrepretation
- Executive summary:
The substance is non-irritating to the rabbit eye.
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