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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Toxic properties after a single oral dose of the test substance were investigated by observation for a period of 14 days.
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl salicylate
EC Number:
204-265-5
EC Name:
Ethyl salicylate
Cas Number:
118-61-6
Molecular formula:
C9H10O3
IUPAC Name:
ethyl 2-hydroxybenzoate
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
0.34, 0.67, 1.31, 2.56 and 5.0 g/kg
No. of animals per sex per dose:
10 animals per dose group
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 320 mg/kg bw
Based on:
test mat.
95% CL:
>= 1.01 - <= 1.63
Mortality:
0/10 at dose level 340 mg/kg bw
0/10 at dose level 670 mg/kg bw
5/10 at dose level 1310 mg/kg bw
10/10 at dose level 2560 mg/kg bw
10/10 at dose level 5000 mg/kg bw
Clinical signs:
other: - 0.34 - 2.56 g/kg: none; - tremors, labored breathing,flaccid at 5 g/kg
Gross pathology:
not specified
Other findings:
not specified

Any other information on results incl. tables

Distribution of mortality

    Observation Day
Dose (g/kg) Deaths/No. of Animals 1 2 3 4 5 6 7 8 9 10 11 12 13 14
0.34 0/10  
0.67 0/10  
1.31 5/10 3 2  
2.56 10/10 10  
5 10/10 10                          

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The test substance has an LD50 of 1320 mg/kg bw given as a single dose.
Executive summary:

The study has been performed in order to investigate the toxic propreties of the test substance. Each group of 10 rats were fed orally 0.34, 0.67, 1.31, 2.56 or 5.0 g/kg of test substance as a single dose. The animals were observed for 14 days.

As a result, the test substance can be referred to as a category 4 compound with an LD50 of 1320 mg/kg bw.