Registration Dossier
Registration Dossier
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EC number: 423-800-5 | CAS number: 7305-71-7
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-07-12 to 1996-08-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- 1992
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-amino-5-methylthiazole
- EC Number:
- 423-800-5
- EC Name:
- 2-amino-5-methylthiazole
- Cas Number:
- 7305-71-7
- Molecular formula:
- C4 H6 N2 S
- IUPAC Name:
- 5-methyl-1,3-thiazol-2-amine
Constituent 1
Study design
- Analytical monitoring:
- yes
Duration of testopen allclose all
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 50 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 50 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 50 mg/L
- Number of replicates:
- 2 replicates each pH and each incubation period.
- Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Preliminary study:
- The study was finished after the preliminary test. The observed degradation after 5 days at 50°C was less than 10% at all three pH-values (4,7,9). Therefore, it was not necessary to perform the main test. It was found that the substance is hydrolytically stable under the conditions of the test. The average pH-values of all samples were within the tolerance range as stated in the test guideline.
- Transformation products:
- not specified
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 96.2
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- ca. 100
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- ca. 100
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
Dissipation DT50 of parent compound
- Remarks on result:
- hydrolytically stable based on preliminary test
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- It was found that the substance is hydrolytically stable under the conditions of the test.
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