Registration Dossier
Registration Dossier
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EC number: 423-800-5 | CAS number: 7305-71-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- Guinea pig maximisation test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- At the time of the test in 1992, the LLNA method was not yet scientifically established.
Test material
- Reference substance name:
- 2-amino-5-methylthiazole
- EC Number:
- 423-800-5
- EC Name:
- 2-amino-5-methylthiazole
- Cas Number:
- 7305-71-7
- Molecular formula:
- C4 H6 N2 S
- IUPAC Name:
- 5-methyl-1,3-thiazol-2-amine
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Pirbright white
- Sex:
- male/female
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 50%. No with. + reactions: 0.0. Total no. in groups: 20.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 50% . No with. + reactions: 0.0. Total no. in groups: 20.0.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information
- Conclusions:
- According to the OECD guideline for testing of chemieals (OECD 406, May 12, 1981), since no animal showed an allergic response,
the test article "AMTH" may be classified as a "non-sensitizer". - Executive summary:
The potential skin sensitizing properties of "AMTH" were assessed in the guinea pig maximization test using 20 test and 20 control animals. Following induction exposure to the test article or the vehicle, the animals were subjected two weeks later to a challenge exposure with the test article. The treated skin areas were evaluated 24 and 48 h after the end of the exposure period.
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