Registration Dossier
Registration Dossier
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EC number: 480-880-4 | CAS number: 608-23-1
Endpoint summary
Administrative data
Description of key information
Key values for acute aquatic toxicity
Aquatic plants: 72h-ErC50 (Selenastrum capricornutum) = 3.21 mg/L (geometric mean measured)
Invertebrates: 48h-EC50 (Daphnia magna, immobilisation) = 1.05 mg/L (mean measured)
Fish: 96h-LC50 (Pimephales promelas, mortality) = 2.43 mg/L (mean measured)
Key values for chronic aquatic toxicity
Aquatic plants: 72h-NOEC (Selenastrum capricornutum, biomass / growth rate) = 0.66 mg/L (geometric mean measured)
Key values for toxicity to microorganisms
Microorganisms: 3h-EC50 (activated sludge, total respiration inhibition) > 7 mg/L (nominal); 3h-NOEC (activated sludge, total respiration inhibition) >= 7 mg/L (nominal)
Additional information
Acute aquatic toxicity
Reliable key studies were available for three trophic levels, i.e. algae, daphnia and fish. The submission substance caused acute adverse effects in all aquatic species. Daphnids were the most sensitive environmental organism.
Acute toxicity to fish
A reliable key study was available performed according to OECD 203 and in compliance with GLP (RL1, 2003). Exposure of fathead minnows to the submission substance resulted in a 96h-LC50 of 2.43 mg/L. The 96h-NOEC was 0.757 mg/L 3-chloro-o-xylene, the lowest tested concentration (this concentration allowed 100% survival with no sublethal effects).
Acute toxicity to aquatic invertebrates
A reliable key study was available performed according to OECD 202 and in compliance with GLP (RL1, 2003). Exposure of daphnids to the submission substance resulted in a 48h-EC50 of 1.05 mg/L. Deviation from the test guideline were considered to not affect the outcome of the toxicity test.
Acute toxicity of aquatic algae
A reliable key study was performed according to OECD 201 and in compliance with GLP (RL1, 2003). Exposure of algae to the submission substance resulted in a 72h-EbC50 of 1.44 mg/L and 72h-ErC50 of 3.21 mg/L based on biomass and specific growth rate, respectively.
Chronic aquatic toxicity
Long-term aquatic toxicity of the submission substance was observed in algae.
Chronic toxicity of aquatic algae
A reliable key study was available performed according to OECD 201 and in compliance with GLP (RL1, 2003) (see also summary above: Acute toxicity of aquatic algae). The 72h-NOEC was 0.66 mg/L 3-chloro-o-xylene for both endpoints, biomass and growth rate.
Toxicity to microorganisms
The submission substance did not show signs of toxicity to STP microorganisms up to a test concentration of 7 mg/L 3-chloro-o-xylene. The reliable key study was performed according to OECD 209 and in compliance with GLP (RL2, 2003). The 3h-EC50 for activated sludge was therefore > 7.0 mg/L and the 3h-NOEC (activated sludge, total respiration inhibition) >= 7 mg/L.
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