Isopropyl benzoate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation / corrosion, other

Remarks:

Pre-existing in vivo study.

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1999

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: According to GLP, however, documentation is incomplete.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Isopropyl benzoate

EC Number:

213-361-6

EC Name:

Isopropyl benzoate

Cas Number:

939-48-0

Molecular formula:

C10H12O2

IUPAC Name:

propan-2-yl benzoate

Constituent 2

Reference substance name:

IPB

IUPAC Name:

IPB

Test material form:

other: Liquid

Details on test material:

- Name of test material (as cited in study report): Isopropyl Benzoate (IPB)
- Stability under test conditions: Stable
- Storage condition of test material: Ambient Temperature

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
No details on the test animals were provided in the report.

Test system

Type of coverage:

not specified

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Remarks:

0.5 ml

Controls:

no

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): None
VEHICLE: None

Duration of treatment / exposure:

4 hours. After 4 hours of exposure the skin was cleaned and decontaminated with water.

Observation period:

1 hr and 1, 2 and 3 days after exposure.

Number of animals:

Three

Details on study design:

- Area of exposure: Shaved flank
REMOVAL OF TEST SUBSTANCE
- Washing with water: Yes
- Time after start of exposure: 4 hrs
SCORING SYSTEM:
Draize scale

Results and discussion

In vivo

Results

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: Mean scores calculated from 1, 2 and 3 day readings

Score:

0

Max. score:

4

Remarks on result:

other: No measurable erythema or edema

Irritant / corrosive response data:

There was no measurable irritation or corrosive response on three rabbits tested.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The test substance was non-irritating following a single four hour application to rabbit skin. The test was conducted on three rabbits.