Registration Dossier
Registration Dossier
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EC number: 213-361-6 | CAS number: 939-48-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Orally administered benzoate esters are metabolised to benzoic acid and the corresponding alcohol. These are readily broken down and excreted.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
Orally administered benzoate esters are metabolised to benzoic acid and the corresponding alcohol. These are readily broken down and excreted.
Aromatic esters are hydrolysed in vivo by the catalytic activity of carboxylesterases,which are found predominantly in hepatocytes. All the benzyl and benzoate esters and acetals of benzaldehyde (or acetaldehyde) are anticipated to be hydrolysed readily under acidic conditions to yield benzyl alcohol (and carboxylic acids) and to benzaldehyde (and alcohols), respectively, followed by oxidation to yield benzoic acid. Benzoate esters are hydrolysed to benzoic acid (and alcohols).The remaining alcohol or acid components formed by hydrolysis are simple aliphatic substances, which are either oxidized to polar metabolites and excreted or metabolized in the fatty acid pathway and tricarboxylic acid cycle.
Benzyl derivatives have been shown to be absorbed rapidly in the gut, metabolized primarily in the liver and excreted in the urine as glycine conjugates of benzoic acid derivatives. Once absorbed, benzyl derivatives are oxidized and excreted primarily as the glycine conjugateof benzoic acid (hippurate).
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