Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-744-4 | CAS number: 26495-91-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb 12 - March 26, 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- adopted 24 Feb, 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 454-780-6
- EC Name:
- -
- Cas Number:
- 27445-54-1
- Molecular formula:
- Hill formula: C12H27NO2Si CAS formula: C12H27NO2Si
- IUPAC Name:
- Cyclohexyl-((diethoxy-methyl-silanyl)-methyl)-amine
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: HsdBrlHan : WIST rats (Full-Barrier)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Body weight at the commencement of the study: male 194 - 216 g and female 194 - 200 g. 5 male and 5 female animals were used.
- The animals were derived from a controlled full barrier maintained breeding system (SPF).
- Source: Harlan Winkelmann GmbH, D-33178 Borchen.
Husbandry
The animals were barrier maintained (semi-barrier) in an air conditioned room
Temperature: 22 ± 3°C
ReI. humidity: 55 ± 10%
Artificial light, sequence being 12 hours light, 12 hours dark
Air change: 10 x / hour
Feeding ad libitum, Altromin 1324 maintenance diet for rats and mice,
totally-pathogen-free (TPF)
Free access to tap water (drinking water, municipal residue control, microbiol. controlled periodically)
The animals were kept in Macrolon cages on Altromin saw fiber bedding Certificates of food, water and bedding are filed at BSL Bioservice
Adequate Acclimatization period
Preparation of the Animals:
The animals were marked for individual identification by tail painting.
Approximately 24 hours before the test, fur was removed from the dorsal area ofthe trunk by clipping.
Not less than 10% ofthe body surface was cleared for the application.
Prior to the first application a detailed clinical observation was made of all animals.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test item was applied to the patch first, and then applied to the skin. Test item was held in contact with the skin with a gauze-dressing and nonirritating tape and was fixed with an additional dressing in a suitable manner.
- Duration of exposure:
- Test item was held in contact with the skin throughout a 24-hour period. At the end of the exposure, residual test item was removed by using tap water.
- Doses:
- The test item was applied at a single dose (2000 mglkg bw) by applying uniformly over an area which was approx. 10% ofthe total body surface.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Animals were observed for 14 days after dosing.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality
- Clinical signs:
- other: No clinical signs of toxicity were observed throughout the observation period. The skin at the application site showed no changes
- Gross pathology:
- Beside acute injection of blood vessels in the abdominal region, which is due to the euthanasia injection no special gross pathological changes were found in any animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Considering the reported data of this dermal toxicity test it can be stated that the test item did not show relevant toxicity under the conditions of the test.
The LDso was determined to be > 2000 mg/kg bw. - Executive summary:
A acute dermal toxicity test according to OECD Guideline No. 402 was performed with the test item.
Considering the reported data of this dermal toxicity test it can be stated that the test item did not show relevant toxicity under the conditions of the test.
The LDso was determined to be > 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.