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Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
according to guideline
OECD Guideline 105 (Water Solubility)
Type of method:
flask method
Water solubility:
1 322 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
8 g/L
25 °C

If the concentrations measured in at least the 2 last vessels do not differ by more than 15%, the test is satisfactory. If the results from vessels 1, 2 and 3 show a tendency of increasing values, the whole test should be repeated using longer equilibration times.

The measured amounts of test substance (c = 8.0 g/L) in water after 24, 48 and 72 h are shown below.

24 h

48 h

72 h

1287.45 mg/L

1349.90 mg/L

1328.50 mg/L


The average water solubility is: 1322 mg/L.

In a second experiment 984 mg of test item were solved in 1 L water. The whole amount of test item dissolved and clear aqueous solutions (pH = 3.57) were obtained.

The recovery rate of 101% determined by HPLC/MS lies within the accepted range of 98 to 102 % and is in agreement with DIN EN 15527:2008 -9.

Description of key information

1322 mg/L at 25 °C and pH 3.57 (OECD 105, flask method)

Key value for chemical safety assessment

Water solubility:
1 322 mg/L
at the temperature of:
25 °C

Additional information