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EC number: 256-370-0 | CAS number: 49556-16-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09.11.2017 - 20.02.2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Tin(2+) neodecanoate
- EC Number:
- 256-370-0
- EC Name:
- Tin(2+) neodecanoate
- Cas Number:
- 49556-16-3
- Molecular formula:
- C20H38O4Sn
- IUPAC Name:
- λ²-tin(2+) bis(2,2-dimethyloctanoate)
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: approx. 8 weeks at start of administration
- Weight at study initiation: first step 177.0 ± 6.1 g (dose group 2000 mg/kg) and second step 183.3 ± 11.4 g (dose group 2000 mg/kg) at day of application
- Fasting period before study: 16 hours
- Housing: Three rats were housed in one Makrolon cage type III plus
- Diet (e.g. ad libitum): Commercial diet, ssniff® R/M-H V1534 served as food
- Water (e.g. ad libitum): ad libitum, drinking water in bottles
- Acclimation period: at least 5 adaptation days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C ± 3°C
- Humidity (%): 55% ± 15% (maximum range)
- Air changes (per hr): 12 to 18-fold air change per hour
- Photoperiod (hrs dark / hrs light): The rooms were lit (about 150 lux at approx. 1.50 m room height) and darkened for periods of 12 hours each.
IN-LIFE DATES: From: 13.11.2017 To: 18.01.2018
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg bw (two steps)
- No. of animals per sex per dose:
- 6 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation: Observations were performed before and immediately, 5, 15, 30 and 60 min, as well as 3, 6 and 24 hours after administration. All animals were observed for a period of 14 days; weighing: before dosing , after 7 days and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathological changes, no histopathology was carried out as no macroscopical findings were noted at autopsy.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- 2000 mg/kg bw - in the first and second step no animal died
- Clinical signs:
- other: 2000 mg/kg bw: no symptoms of toxicity
- Gross pathology:
- The necropsy 14 days after oral application showed no test substance related macroscopic visible pathologic organ findings in the survived animals.
No pathological changes were observed at necropsy.
Applicant's summary and conclusion
- Conclusions:
- The LD50-value for acute oral toxicity of the test substance neodecanoic acid tin (2+)salt (2:1) is > 2000 mg/kg body weight.
- Executive summary:
In an acute oral toxicity study performed according to the OECD Guideline 423, (Acute Toxic Class Method, 2001), 6 female 8 weeks old Crl: CD(SD) rats per group were given a single oral dose of test substance neodecanoic acid tin (2+)salt (2:1) at a dose of 2000 mg/kg bw and observed for 14 days.The test substance was applied undiluted.
The test substance was tolerated by the test animals at a dose of 2000 mg/kg body weight without any symptoms of toxicity. All animals gained the expected body weight at the end of the study period. No pathological changes were observed at necropsy. The LD50value was ranked exceeding 2000 mg/kg b.w.
The LD50-value for acute oral toxicity of the test substance neodecanoic acid tin (2+)salt (2:1) is > 2000 mg/kg body weight.
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