Registration Dossier

Administrative data

Endpoint:
long-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Validated industry computer model that is appropriate for use with this petroleum substance
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the PETROTOX computer model. This model combines Target Lipid Model used to calculate acute and long-term toxicity of non-polar narcotic chemicals with a partitioning model used to calculate the aqueous concentration of hydrocarbon components.PETROTOX calculates toxicity based on the combined total of membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and selected organism and the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance.
GLP compliance:
no
Remarks:
The data were calculated by a computer model.

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test organisms

Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)

Study design

Test type:
other: QSAR modelled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
14 d

Test conditions

Reference substance (positive control):
not required

Results and discussion

Effect concentrations
Duration:
14 d
Dose descriptor:
other: NOEL
Effect conc.:
0.068 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality

Applicant's summary and conclusion

Executive summary:

The aquatic toxicity was estimated by a QSAR, the PETROTOX computer model. This model combines Target Lipid Model used to calculate acute and long-term toxicity of non-polar narcotic chemicals with a partitioning model used to calculate the aqueous concentration of hydrocarbon components. PETROTOX calculates toxicity based on the combined total of membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and selected organism and the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance. The estimated freshwater fish NOEL (No Observed Effect Level) value is 0.068 mg/l based on mortality.