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EC number: 479-410-0
CAS number: -
Equivalent to OECD dermal carcinogenicity study, GLP compliant, on analogous substance Distillate (Petroleum), hydrotreated middle.
Thus Renewable Diesel should not be classified as carcinogenic under
67/548/EEC or CLP regulation (1272/2008), being produced from
non-carcinogenic feedstock, having a very low mutagenic/carcinogenic
polycyclic aromatic (3+/4+ ring) content and closely resembling gas oil
samples shown to be non-carcinogenic or at most locally-acting,
non-genotoxic carcinogens via a repetitive wounding mechanism.
In a 2 year dermal carcinogenicity study conducted on an analogous
substance (Distillates (Petroleum), hydrotreated middle) using mice,
there was a clear link between degree of dermal irritation and localised
tumour formation. The two lower doses tested (28.5% and 50%) which
produced less severe dermal irritation did not produce statistically
significant increases in the number of skin tumours compared with the
Based on the results of this study, it is predicted that prolonged and
repeated application of undiluted material (Renewable Diesel) to the
skin would prove highly irritating: over the lifespan of a rodent: the
consequent skin damage is likely to prove sufficient to cause localised
tumours through a non-genotoxic, repetitive skin insult mechanism.
However distant tumours would not be expected.
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