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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Safety Evaluation of Selenium Sulfide Antidandruff Shampoos
Author:
LAURENCE M., CUMMINS AND EUGENE T. KIMURA
Year:
1971
Bibliographic source:
TOXICOLOGY AND APPLIED PHARMACOLOGY 20,89-96 (1971)

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
methylcellulose
Doses:
0.1 to 20%
No. of animals per sex per dose:
6 rats per dose, 30 to 36 rats total
Control animals:
not specified
Details on study design:
7-10 days observation following treatment
Statistics:
95% CL, Litchfield and Wilcoxon (1949)

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 400 mg/kg bw
Based on:
act. ingr.
95% CL:
>= 342 - <= 469
Mortality:
not specified
Clinical signs:
not specified
Body weight:
between 50 and 100 g
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Administration of benzalkonium chloride in 30 to 36 Sprague-Dawley rats by oral route: LD50 of 400 mg/kg bw.
Executive summary:

Administration of benzalkonium chloride in Sprague-Dawley rats by oral route: LD50 of 400mg/kg