Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22/09/2017-25/09/2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes (incl. certificate)
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Sample identification : 17.076961.0001
Batch Number:Lot 91602E004 20/06/17
Purity:70% w/w of CAS 7281-04-1 and 30% w/w of CAS 18773-88-1 (stated)
Storage:Store at RT

Sample preparation : About 0,5 g in 50 ml of Water / Methanol = 5/95 (detection with RID)
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
ca. 2.27
Temp.:
25 °C
pH:
ca. 6
Remarks on result:
other:
Remarks:
this log Pow as valid although of less significance
Key result
Type:
log Pow
Partition coefficient:
ca. 2.82
Temp.:
25 °C
pH:
ca. 6
Remarks on result:
other:
Remarks:
this log Pow as valid although of less significance
Details on results:
The partition coefficient n-octanol/water is not determinable since the active substance is a surfactant in the octanol/water system.
The HPLC Method is not applicable either, due to the absence of suitable calibration compounds and to the fact that ionic compounds interact with the HPLC column by forces other than partitioning.
Although Log Pow value was still experimentally determined, this is of less significance due to the consideration aforementioned
Eluant (water and methanol) pH is used for analysis, then set to 6 approximately.
Conclusions:
The partition coefficient n-octanol/water is not determinable since the active substance is a surfactant in the octanol/water system. Although Log Pow value of 2.39 was still experimentally determined, this is of less significance due to the consideration aforementioned
Executive summary:

The partition coefficient n-octanol/water is not determinable since the active substance is a surfactant in the octanol/water system. Although Log Pow value of 2.39 was still experimentally determined in an OECD 117 study, this is of less significance due to the consideration aforementioned

Description of key information

The partition coefficient n-octanol/water is not determinable since the active substance is a surfactant in the octanol/water system. Although Log Pow value of 2.39 was still experimentally determined in an OECD 117 study, this is of less significance.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.39
at the temperature of:
25 °C

Additional information