Registration Dossier
Registration Dossier
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EC number: 309-916-8 | CAS number: 101357-19-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: D.N.Noakes & D.M.Sanderson (A Method for Determining the Dermal Toxicity of Pesticides; Brit. Journ. Ind. Med. 26, 59, 1969)
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Similar substance 02
- IUPAC Name:
- Similar substance 02
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wiga
- Weight at study initiation: 107 - 152 g
- Housing: not specified
ENVIRONMENTAL CONDITIONS
not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Remarks:
- aqua dest.
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back, 50 cm²
- % coverage: not specified
- Type of wrap if used: not specified
REMOVAL OF TEST SUBSTANCE
- Washing: yes
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount applied: 2500 mg/kg
- Concentration: 50 % - Duration of exposure:
- 24 h
- Doses:
- 2500 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 1, 24, 48 h, 7, 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 500 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality
- Clinical signs:
- other: no results
- Gross pathology:
- no results
- Other findings:
- Purple remains of the test substance were observed throughout the study period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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