Registration Dossier
Registration Dossier
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EC number: 201-744-0 | CAS number: 87-41-2
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 Jan - 6 Feb 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- column elution method
Test material
- Reference substance name:
- Phthalide
- EC Number:
- 201-744-0
- EC Name:
- Phthalide
- Cas Number:
- 87-41-2
- Molecular formula:
- C8H6O2
- IUPAC Name:
- 1,3-dihydro-2-benzofuran-1-one
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- < 1.5 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7.3
Any other information on results incl. tables
- Preliminary test
The sample was tested as received. No further preliminary treatment such as drying or milling was performed. The results given in this report only apply to the tested sample.
Mobile phase: Acetonitrile / demineralized water, gradient (see Table 1)
Table 1: Gradient of the mobile phase
Time/ min | Acetonitrile I % | Water I % |
0 | 75 | 25 |
3 | 100 | 0 |
Flow rate: 1 ml/min
Injection volume: 100 µI Detection wavelength: 228 nm
Three preliminary tests were carried out with specified amounts of the test item and 100 ml and 500 ml demineralized water, respectively. After each addition of an amount of water, the mixture was stirred for at least 24 hours, and visually checked for any undissolved particles.
Table 4: Results of the preliminary test
Amount of test item / mg | Total volume of demineralized water I ml | Appearance of mixture |
12.4 | 100 | not dissolved |
11.5 | 500 | not dissolved |
2.7 | 500 | not dissolved |
The preliminary test showed that the water solubility of the test item is < 10 mg/L. According to the preliminary test the water solubility was determined by the column elution method in the main test.
The water solubility cs of the test item at a temperature of 20 °C was determined according to the column elution method. It was found to be below the quantification limit:
Cs < 1.5 mg/L
Applicant's summary and conclusion
- Executive summary:
The water solubility of the test substance was < 1.5 mg/L.
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