Registration Dossier
Registration Dossier
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EC number: 602-791-3 | CAS number: 122584-18-3
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient documentation for an assessment of reliability.
- GLP compliance:
- not specified
- Medium:
- methanol
- Solubility:
- 26 g/L
- Temp.:
- 20 °C
- Medium:
- ethanol
- Solubility:
- 18 g/L
- Temp.:
- 20 °C
- Medium:
- isopropanol
- Solubility:
- 6.3 g/L
- Temp.:
- 20 °C
- Medium:
- other: dichloromethane
- Solubility:
- 0.82 g/L
- Temp.:
- 20 °C
- Medium:
- other: 2-propanone
- Solubility:
- 26 g/L
- Temp.:
- 20 °C
- Medium:
- ethyl acetate
- Solubility:
- 4.8 g/L
- Temp.:
- 20 °C
- Medium:
- other: methylbenzene
- Solubility:
- 0.09 g/L
- Temp.:
- 20 °C
- Medium:
- other: 4-methyl-2-pentanone
- Solubility:
- 4.3 g/L
- Temp.:
- 20 °C
- Medium:
- other: 2-butanone
- Solubility:
- 16 g/L
- Temp.:
- 20 °C
- Details on results:
- no data
Reference
Table 1 Solubility of the T002078 at 20 deg C
| Solvent | Solubility in g/L solution |
| tetrahydrofuran | 94 |
| 1 -methoxy-2-propanol | 41 |
| N,N-dimethylacetamide | > 300 |
| acetic acid | 14 |
Description of key information
A K4 study reports various solubilities of test substance in different organic solvents (J&J PRD).
Key value for chemical safety assessment
Additional information
| solvent | solubility g/L (20°C) |
| methanol | 26 |
| ethanol | 18 |
| 2-propanol | 6.3 |
| dichloromethane | 0.82 |
| 2-propanone | 26 |
| ethyl acetate | 4.8 |
| methylbenzene | 0.09 |
| 4-methyl-2-pentanone | 4.3 |
| 2-butanone | 16 |
| 1-methoxy-2-propanol | 41 |
| N,N-dimethylacetamide | >300 |
| acetic acid | 14 |
| acetic acid/water (10/90, v/v) (pH=2.10) | 0.03 |
| THF | 94 |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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