Registration Dossier
Registration Dossier
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EC number: 232-108-0 | CAS number: 7787-32-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Barium fluoride will dissociate in aqueous solution to form barium and fluoride ions. Reliable toxicity data on micro-organisms are available for barium and fluoride. Regarding toxic effects of dissolved Ba, 3h-IC50 and 3h-NOEC values of >622 and ≥622 mg Ba/L, respectively, were determined by Egeler and Kiefer (2010) corresponding to the 3h-IC50 and 3h-NOEC values of >794 and ≥794 mg BaF2/L.
For fluoride an EC10 of 510 mg/L was observed in an activated sludge test which would correspond to 2353 mg BaF2/L. When comparing the effect levels of Ba and F, it can be concluded that the toxicity to micro-organisms is driven by barium resulting in a 3h-NOEC of 794 mg BaF2/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 794 mg/L
Additional information
For barium fluoride no data on toxicity to micro-organisms are available. As barium fluoride in water rapidly dissociates into barium and fluoride ions, it is these ions that are expected to be present in the environment and which will therefore be assessed. Reliable toxicity data on micro-organisms are available for barium and fluoride ions.
Barium
A GLP-compliant OECD guideline 209 study is available for barium (Egeler et al., 2010). In this 3 -hour respiration inhibition test, activated sludge (from a municipal sewage treatment plant receiving predominantly domestic sewage) was exposed to barium chloride concentrations of up to 1000 mg/L.An inhibition of the respiration rate was not observed at the highest tested concentration. The 3h-IC50 and 3h-NOEC amount to >622 and ≥622 mg Ba/L,based on total measured barium, corresponding to a 3h-IC50 and 3h-NOEC of >794 and ≥794 mg BaF/L, respectively.
Fluoride
In the EU Risk Assessment Report for hydrogen fluoride several studies with micro-organisms are reported (EU-RAR, 2001). The long-term NOEC-values for microorganisms range from 7.1 to 510 mg/L. In the EU-RAR it is concluded that only the results of an activated sludge test (3h-EC10 value of 510 mg fluoride/L) and a test on Pseudomonas putida (NOEC of 231 mg fluoride/L) can theoretically be used for deriving a PNEC for microorganisms. As the EC10 -value of 510 mg fluoride/L from the activated sludge test brings about the lowest PNEC, this study is concluded to be critical. As no new data have become available since the EU-RAR, this value is used for this substance evaluation.
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