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Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please refer to the analogue justification attached to IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
> 320 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Duration:
72 h
Dose descriptor:
EC10
Effect conc.:
> 320 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Validity criteria fulfilled:
yes
Conclusions:
Since no inhibition effects were observed above 10% up to the highest test item concentration of 320 mg/L the toxicological endpoints of EC10 and EC50 were reported as >320 mg/L.
Executive summary:

One experimental study is available investigating the toxicity of the analogous substance to aquatic freshwater algae. The study was conducted according to OECD 201 (GLP) using the freshwater algae Pseudokirchneriella subcapitata. The definitive test was carried out with the following concentration range: control, 3.2, 10, 32, 100 and 320 mg test item/L (nominal). The measured concentrations of the test item at test start (0h) and test end ranged between 90% and 109% of the nominal values. Thus, it is justified that the effect concentrations are based on the nominal concentrations. Inhibition of growth was recorded resulting in an ErC10 and ErC50 (72h) of >320 mg/L. Inhibition of yield was recorded resulting in an EyC10 and EyC50 (72 h) of >320 mg/L.

Description of key information

ErC50 (72h) >320 mg/L (P. subcapitata, OECD 201, nominal, read-across)

ErC10 (72h) >320 mg/L (P. subcapitata, OECD 201, nominal, read-across)

Key value for chemical safety assessment

Additional information

No data are available on the toxicity towards aquatic algae of p-anisic-acid (CAS No. 100-09-4). Therefore data from the analogue substance sodium anisate (CAS 536-45-8) were used for read across. This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in within the analogue justification in IUCLID Section 13.

One experimental study is available investigating the toxicity of the substance to aquatic freshwater algae. The study was conducted according to OECD 201 (GLP) using the freshwater algae Pseudokirchneriella subcapitata. The definitive test was carried out with the following concentration range: control, 3.2, 10, 32, 100 and 320 mg test item/L (nominal). The measured concentrations of the test item at test start (0h) and test end ranged between 90% and 109% of the nominal values. Thus, it is justified that the effect concentrations are based on the nominal concentrations. Inhibition of growth was recorded resulting in an ErC10 and ErC50 (72h) of >320 mg/L. Inhibition of yield was recorded resulting in an EyC10 (72 h) of 115 mg/L and EyC50 (72 h) of >320 mg/L.