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EC number: 701-404-6
CAS number: -
The acute oral median lethal dose (LD50) of the test material in the
Spra~ue-DawlevC D (Crl: CD@
JSD) IGS BR) strain rat was estimated to be in the range of 200 - 500
mgntg: bodvweight. Mortalities
were noted at dose levels of 2000 and 500 mgke bodwei~ht. No mortalities
were noted in animals
treated with 200 mag: bodweight.
A group of three fasted females was treated with 2000 mgkg bodyweight.
Based on the results fiom this
dose level a further group of fasted male and female animals was treated
at a dose level of 200 m a g
bodyweight. At the request of the study sponsor, an additional group of
three fasted females was treated
with 500 mgkg bodyweight. Dosing was performed sequentially.
The test material was administered orally as a solution in distilled
water. Clinical signs and bodyweight
development were monitored during the study. All animals were subjected
to gross necropsy.
All animals treated at dose levels of 2000 or 500 mgkg were found dead
during the day of dosing. There
were no deaths at 200 mgkg.
Signs of systemic toxicity noted at a dose level of 2000 m a g were
ataxia, pallor of the extremities,
hunched posture, lethargy, ptosis, decreased respiratory rate, labored
respiration and loss of righting reflex.
Signs of systemic toxicity noted at a dose level of 500 mgkg were
hunched posture and ataxia. There were
no signs of systemic toxicity noted at a dose level of 200 m a g .
The surviving animals showed expected gains in bodyweight over the study
Abnormalities noted at necropsy of the animals that died during the
study were abnormally red lungs, dark
liver or patchy pallor of the liver, dark kidneys, hemorrhage and
epithelial sloughmg of the gastric mucosa,
hemorrhage andlor sloughmg of the non-glandular epithelium of the
stomach and hemorrhage of the small
intestines. A pale appearance of the kidneys was noted at necropsy of
one male treated with 200 mgkg that
was killed at the end of the study. No abnormalities were noted at
necropsy of all other animals that were
9 killed at the end of the study.
Based on the available endpoints for acute toxicity the substance was
classified as Acute oral Cat 4, H302: Harmful if swallowed.
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