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EC number: 701-404-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
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- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
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- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
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- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- This study was conducted between 12 December 2016 and 23 June 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study is considered to be a reliability 1 as it has been conducted according to OECD TG 105 using an adapted flask method and in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- EC No. 440/2008 of 30 May 2008
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Specific details on test material used for the study:
- Identification: 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with diethylenetriamine
Appearance/Physical state: Yellow/brown extremely viscous liquid
Batch: Ei3041
Purity: 100% UVCB
Expiry date: 01 May 2021
Storage conditions: Room temperature in the dark
The test item was heated to a maximum of 80 °C to enable sampling for testing. - Key result
- Water solubility:
- > 95 vol%
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- ca. 11.4
- Conclusions:
- The miscibility of the test item has been determined to be greater than 95% w/w of solution at 20.0 ± 0.5 ºC.
- Executive summary:
The general physico-chemical properties of 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with diethylenetriamine have been determined.
Water Solubility. Miscible greater than 95% w/w, usingan adapted flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Reference
Preliminary Test
The preliminary estimate of water solubility was greater than 2.6g/L at20.0°C.
Definitive test
The results of the definitive test for the water solubility are shown in the following table:
Concentration (% w/w) |
Observation |
pH |
5.00 |
Almost colorless, clear, single phase solution, no undissolved test item |
11.2 |
27.7 |
Clear, slightly viscous, pale yellow, single phase solution, no undissolved test item |
11.5 |
49.6 |
Clear, viscous, pale yellow, single phase solution, no undissolved test item |
11.6 |
75.6 |
Clear, extremely, viscous, yellow single phase solution, no undissolved test item/water |
n/a |
94.8 |
Clear extremely viscous (non-malleable) yellow, single phase solution, no undissolved test item/water |
n/a |
Miscibility greater than 95% w/w at 20.0 ± 0.5 ºC.
Discussion
The standard EC method A6 and OECD method 105 was not applicable to this test item due to the high indeterminable saturation levels produced. It was therefore not possible to prepare samples at five times the saturation level as recommended in the guidelines. No analysis could be performed for the main test due to the high solubility producing unfilterable mixtures. Therefore the water solubility was determined based on visual inspection.
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 18 140 000 mg/L
- at the temperature of:
- 20 °C
Additional information
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