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Physical & Chemical properties

Vapour pressure

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Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
adopted 23rd March 2006
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance
Specific details on test material used for the study:
Name: LEVOTHYROXINE ACID
Batch No.: B486066
Expiry date: 27 August 2020
Storage condition: at room temperature, protected from light
Appearance: white slightly crème, powder
Key result
Test no.:
#1
Temp.:
ca. 20 °C
Vapour pressure:
ca. 0 Pa
Remarks on result:
other: actual value 8.411 x 10-12 Pa
Test no.:
#2
Temp.:
ca. 25 °C
Vapour pressure:
ca. 0 Pa
Remarks on result:
other: actual value 3.445 x 10-11 Pa
Conclusions:
Vapour pressure of O-METHYL-L-DIIODOTHYRONIN at 20 °C: 8.411 x 10-12 Pa
Vapour pressure of O-METHYL-L-DIIODOTHYRONIN at 25 °C: 3.445 x 10-11 Pa
Executive summary:

The vapour pressure was determined according to EU-method A.4 using a vapour pressure balance system with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25 °C.

Vapour pressure of O-METHYL-L-DIIODOTHYRONIN at 25 °C: 3.445 x 10-11 Pa

Endpoint:
vapour pressure
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Study period:
2021
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Qualifier:
no guideline followed
Principles of method if other than guideline:
The vapor pressure is estimated by the modified Grain
GLP compliance:
no
Type of method:
other: QSAR calculation
Specific details on test material used for the study:
SMILES : c1(I)c(Oc2cc(I)c(O)c(I)c2)c(I)cc(CC(N)C(=O)O)c1
Temp.:
ca. 25 °C
Vapour pressure:
ca. 0 Pa
Conclusions:
The vapour pressure at 25 °C was calculated to 2.73E-014
Executive summary:

The vapour pressure at 25 °C was calculated to 2.73E-014 , using the MPBPVP v1.43 programme. [Modified Grain method]

Description of key information

The vapour pressure was determined according to EU-method A.4 using a vapour pressure balance system with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25 °C.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information