Registration Dossier
Registration Dossier
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EC number: 606-744-8 | CAS number: 213464-77-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Remarks:
- Woolley, Mullee (2002g) IIA 02/11
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Specific details on test material used for the study:
- IR5878 Analytical standard
99.65% pure
Batch number G 032/02
White powder
Store cold approximately 4C in the dark
Date received 23 July 2002 - Key result
- Water solubility:
- ca. 26.2 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 4
- Key result
- Water solubility:
- ca. 629 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 7
- Key result
- Water solubility:
- ca. 38.9 g/L
- Temp.:
- 20 °C
- pH:
- ca. 8.5
- Conclusions:
- Solubility of purified active substance in water
Investigations into the rate of hydrolysis at pH4 indicated the test material had a half life of approximately 14 hours.
Flask method
pH=4 26.2 mg/L at 20°C
pH=7 629 mg/L at 20°C
pH=8.5 38.9 g/L at 20°C - Executive summary:
R5878 is soluble in water, and its solubility increases with the pH value.
The water solubility of the test material at approximately pH4 has been determined to be 26.2 mg/L of solution at approximately 20C.
The water solubility of the test material at approximately pH7 has been determined to be 0.629g/L of solution at approximately 20C.
The water solubility of the test material at approximately pH8.5 has been determined to be 38.9g/L of solution at approximately 20C.
Reference
Description of key information
Solubility of purified active substance in water
Flask method
pH=4 26.2 mg/L at 20°C
pH=7 629 mg/L at 20°C
pH=8.5 38.9 g/L at 20°C
Key value for chemical safety assessment
- Water solubility:
- 629 mg/L
- at the temperature of:
- 20 °C
Additional information
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