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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
• CO2 hop extract from Humulus lupulus ‘Cascade’; Batch No 160024: 34.97% α-acids, 37.05% β-acids, 8.23% volatile oil.
• CO2 hop extract from Humulus lupulus ‘Cascade’; Batch No 160026: 36.55% α-acids, 35.19% β-acids, 7.66% volatile oil.
• Oil-enriched CO2 hop extract from Humulus lupulus ‘Target’; Batch No BI/YYF/1701: 25.98% α-acids, 7.72% β-acids, 30.6% volatile oil.
Analytical method:
liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
> 3 - < 7
Temp.:
40 °C
pH:
ca. 7
Remarks on result:
other: Hop extract is a hydrophobic UVCB substance. The principal components have estimated log10KOW values of 4.1, 5.0 and 5.2, but there are some minor components with log10KOW of >5.2.
Conclusions:
Hop extract is a hydrophobic UVCB substance. The principal components have estimated log10KOW values of 4.1, 5.0 and 5.2, but there are some minor components with log10KOW of >5.2.

Description of key information

Key value for chemical safety assessment

Log Kow (Log Pow):
5.2
at the temperature of:
40 °C

Additional information

Figure entered for CSR. Hop extract is a hydrophobic UVCB substance. The principal components have estimated log10KOW values of 4.1, 5.0 and 5.2, but there are some minor components with log10KOW of >5.2.